ABSTRACT
This study was to investigate the regulation of lipopolysaccharides(LPS)-induced sepsis in mice by preadministration of Shenmai injection (SMI)and the therapeutic differences between male and female.The females and males were randomly grouped by weight,including control group,LPS-induced sepsis model group and SMI administration group.After preadministration of SMI for 14 days,10 mg/kg LPS were intraperitoneally injected subsequently to induce sepsis.The survival rate of mice,level of serum cytokines and the mRNA expres-sion of proinflammatory cytokines in main tissues were detected to evaluate the impact of SMI in LPS-induced sepsis mice.From the survival rate,which is considered as a gold standard of improvement in sepsis,significant protective effect can be observed after SMI pretreatment in LPS-induced sepsis mice,a more significant effect was shown in the females.Consisting with the serum cytokines levels,SMI significantly inhibited proinflammatory cyto-kines including IL-6,IL-1βand TNF-αmRNA expression in tissues and the regulation of IL-6 was most signifi-cant,which was consistent with the results of ELISA in serum.Moreover,the liver tissue acquired a more evident impact than any other tissues,which fits with the ratio of dry/wet weight.SMI can significantly inhibit inflammato-ry response by delivery in advance in LPS-induced septic mice,providing strong evidence for elaborating mecha-nism in the treatment of cardiovascular disease related inflammation and shock.
ABSTRACT
As a common postoperative complication after gastrointestinal tumor surgery, the diarrhea adversely affects the recovery and the life quality of the patients. The occurrence of diarrhea is closely related to the operations and the perioperative treatments. Meanwhile,the gastrointestinal microecological disorders are found to be involved. In this article,the author will make a systemic review on the related factors and their treatments of the postoperative diarrhea after gastrointestinal tumor surgery, and mainly discuss the microecological issues involved in these processes.
ABSTRACT
From the aspects of strengths,weaknesses,opportunities and threats,this paper analyzed external factors of the reorganizations and group building reform of public hospitals in Shanghai.Points made are as follows:Characteristics of individual hospitals should he respected instead of a generalized pattern for all;the role of the government to play in this regard should he guidance of an orderly competition,Strengthen Supervision,and promotion of the reform in property rights,These efforts will create a desirable environment for hospital groups;mid- and long-term goals for the reform should consolidate the independent legal entity status of such groups.